T Cell Ig and Mucin 1 (TIM-1) is Expressed on in Vivo-activated T Cells and Provides a Costimulatory Signal for T Cell Activation

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2005 Nov 15

PMID 16284246

Citations 86

Authors

Anjali J de Souza

Timothy B Oriss

Katherine J OMalley

Anuradha Ray

Lawrence P Kane

Affiliations

Soon will be listed here.

Abstract

Polymorphisms in TIM-1, a member of the T cell Ig and mucin (TIM) domain family, are associated with relative susceptibility to the development of T helper 2-dominated immune responses such as in allergic asthma. Recent data have also suggested that ligation of TIM-1 can augment T cell activation. We have found that the TIM-1 protein is expressed on CD4(+) T cells in vivo after intranasal immunization. Ectopic expression of TIM-1 during T cell differentiation results in a significant increase in the number of cells producing IL-4 but not IFN-gamma. Furthermore, TIM-1 expression provides a costimulatory signal that increases transcription from the IL-4 promoter and from isolated nuclear factor of activated T cells/activating protein-1 (NFAT/AP-1) elements. Finally, we provide evidence that TIM-1 can be phosphorylated on tyrosine and that TIM-1 costimulation requires its cytoplasmic tail and the conserved tyrosine within that domain. These results constitute evidence that TIM-1 directly couples to phosphotyrosine-dependent intracellular signaling pathways.

Citing Articles

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