Elevated Serum Nitric Oxide Metabolites in Biliary Atresia

Overview

Journal Pediatr Surg Int

Specialties General Surgery
Pediatrics

Date 2005 Nov 12

PMID 16283336

Citations 2

Authors

Paisarn Vejchapipat

Voranush Chongsrisawat

Apiradee Theamboonlers

Soottiporn Chittmittrapap

Yong Poovorawan

Affiliations

Soon will be listed here.

Abstract

Biliary atresia (BA) remains one of the most intractable liver diseases in children. The aim of this study was to investigate the possible roles of nitric oxide (NO) in BA. Serum levels of nitrite and nitrate (NO production) were determined using a colorimetric method from 65 post-operative BA patients and 12 healthy children. The patients were categorized into two groups according to their jaundice status, and serum alanine aminotransferase (ALT, a marker for liver injury). Unpaired t tests were used. Data are expressed as mean and SD in terms of mumol/l. Age and gender between BA patients and controls were comparable. Serum NO metabolites of BA patients was higher than the controls (79.77+/-21.22 vs. 65.75+/-9.44, P=0.001). Subgroup analysis revealed that there was no difference in serum nitrate/nitrite levels of BA patients without jaundice compared to those with jaundice (78.85+/-23.23 vs. 80.90+/-18.76, P=0.70). However, patients with serum ALT> or =100 IU/l had higher levels of serum NO metabolites compared to those with serum ALT<100 IU/l. In conclusion, NO production was elevated in BA patients compared to normal controls. Serum NO was associated with serum ALT levels, but not with jaundice status, in BA patients. These suggest that NO plays a role in the pathophysiology of liver injury in post-operative BA.

Citing Articles

Pre-operative Hepatic Artery Resistive Index is a Non-invasive Predictive Indicator of Prognosis in Biliary Atresia.

Mittal D, Bhatnagar V, Agarwala S, Srinivas M, Jana M, Gupta A J Indian Assoc Pediatr Surg. 2017; 22(4):237-241.

PMID: 28974877 PMC: 5615899. DOI: 10.4103/jiaps.JIAPS_103_17.

Portal pressure and blood nitric oxide levels as predictors of outcome in biliary atresia.

Khanna V, Bhatnagar V, Agarwala S, Srinivas M, Das N, Singh M J Indian Assoc Pediatr Surg. 2016; 21(2):49-53.

PMID: 27046973 PMC: 4790127. DOI: 10.4103/0971-9261.176931.

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