Parthenogenic Origin of Benign Ovarian Teratomas

Overview

Journal N Engl J Med

Specialty General Medicine

Date 1975 Jan 9

PMID 162806

Citations 69

Authors

D Linder

B K McCaw

F Hecht

Affiliations

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Abstract

To determine the origin of benign cystic teratomas of the ovary, chromosome-banding studies were done on normal tissues and teratomas from five patients. The normal tissues were heterozygous (+/-) for 17 chromosome polymorphisms at or near the centromere, whereas the teratomas were uniformly homozygous (+/+ or -/-). These findings and those employing electrophoretic variants indicate that ovarian teratomas are parthenogenic tumors that arise from a single germ cell after the first meiotic division.

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