Neuropsychological Aspects of Coinfection with HIV and Hepatitis C Virus

Overview

Journal Clin Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2005 Nov 3

PMID 16265612

Citations 31

Authors

Robin C Hilsabeck

Steven A Castellon

Charles H Hinkin

Affiliations

Soon will be listed here.

Abstract

Infection with hepatitis C virus (HCV) is commonly seen in persons with human immunodeficiency virus (HIV) infection, because the viruses share risk factors for transmission; coinfection is a leading cause of morbidity and mortality among HIV-infected persons. Neuropsychological consequences of HIV infection are well established, and studies of HCV-infected persons have revealed neuropsychiatric dysfunction in this population as well. Investigators now are focusing on neuropsychological sequelae of coinfection with HIV and HCV, and preliminary results suggest that coinfection has a possible deleterious effect on global cognitive functioning consistent with frontal-subcortical dysfunction. Data on neuropsychiatric symptoms in coinfected persons are inconclusive at this time and are complicated by important differences in study populations (e.g., injection drug use and disease severity). This review summarizes what is known about neuropsychological aspects of monoinfection with HIV and HCV, as well as coinfection, discusses implications of these findings, and suggests future directions for this research area.

Citing Articles

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Cognitive impairment severity in relation to signs of subclinical Wernicke's encephalopathy in HIV and alcoholism comorbidity.

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Fabbiani M, Ciccarelli N, Castelli V, Soria A, Borghetti A, Colella E J Neurovirol. 2019; 25(6):866-873.

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Cognitive and Motor Impairment Severity Related to Signs of Subclinical Wernicke's Encephalopathy in HIV Infection.

Le Berre A, Fama R, Sassoon S, Pfefferbaum A, Sullivan E, Zahr N J Acquir Immune Defic Syndr. 2019; 81(3):345-354.

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The Aging Brain With HIV Infection: Effects of Alcoholism or Hepatitis C Comorbidity.

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