Effects of a Low Sodium Diet on Bone Metabolism

Overview

Journal J Bone Miner Metab

Specialty Endocrinology

Date 2005 Nov 2

PMID 16261460

Citations 6

Authors

Laura D Carbone

Karen D Barrow

Andrew J Bush

M David Boatright

Jean A Michelson

Kathleen A Pitts

Victorina N Pintea

Andrew H Kang

Mitchell A Watsky

Affiliations

Soon will be listed here.

Abstract

Osteoporosis is a serious public health problem, and dietary interventions may potentially be helpful in preventing this disorder. The purpose of this study was to determine the effects of a low sodium diet on bone metabolism in postmenopausal women. This was a longitudinal study to determine the effects of a low sodium (2-g/day) diet on bone. Forty postmenopausal African-American and Caucasian women were enrolled in a 2-g/day sodium diet for 6 months. Sodium and calcium excretion, bone turnover, and calcitropic hormones (intact parathyroid hormone (PTH) and 1,25 dihydroxyvitamin D) were measured before and 6 months after the intervention. In women who had baseline sodium excretions equal to or greater than the average sodium intake in the United States (> or =3.4 g/day), the low sodium diet resulted in significant decreases in sodium excretion (P = 0.01), in calcium excretion (P = 0.01), and in a biomarker of bone turnover, aminoterminal propeptide of type I collagen (P = 0.04). However, there were no significant changes in calcitropic hormones, including intact PTH (P = 0.97) or 1,25 dihydroxyvitamin D (P = 0.49) with the low sodium diet. These findings suggest that in postmenopausal women with sodium intakes > or =3.4 g/day, a low sodium diet may have benefits for skeletal health.

Citing Articles

Association of low-sodium salt intervention with osteoporosis: A cross-sectional study based on the SSaSS study.

Li X, Wang X, Peng Y, Xia Q, Lu Y, Sun H Arch Osteoporos. 2025; 20(1):12.

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Nutrients in the Prevention of Osteoporosis in Patients with Inflammatory Bowel Diseases.

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Estimation of Prevalence of Osteoporosis Using OSTA and Its Correlation with Sociodemographic Factors, Disability and Comorbidities.

Wang P, Abdin E, Shafie S, Chong S, Vaingankar J, Subramaniam M Int J Environ Res Public Health. 2019; 16(13).

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Bone turnover after bariatric surgery.

Melo T, Froeder L, Baia L, Heilberg I Arch Endocrinol Metab. 2017; 61(4):332-336.

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The relationship between sodium intake and some bone minerals and osteoporosis risk assessment instrument in postmenopausal women.

Vafa M, Soltani S, Zayeri F, Niroomand M, Najarzadeh A Med J Islam Repub Iran. 2016; 30:377.

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