Experimental Treatment for Focal Hyperglycemic Ischemic Brain Injury in the Rat

Overview

Journal Exp Brain Res

Specialty Neurology

Date 2005 Nov 2

PMID 16261339

Citations 3

Authors

Nasim Farrokhnia

Magnus W Roos

Andreas Terent

Fredrik Lennmyr

Affiliations

Soon will be listed here.

Abstract

Hyperglycemia aggravates ischemic brain injury, possibly due to the activation of signaling pathways involving reactive oxygen species, Src and mitogen-activated protein kinases. The aim of this study was to investigate the effects of the spin trap agent alpha-phenyl-N-tert-butyl nitrone (PBN), the Src family kinase inhibitor PP2 and the MEK1-inhibitor U0126 on focal hyperglycemic ischemic brain injury. Temporary middle cerebral artery occlusion (90 min) was induced in four groups of rats (PBN, PP2, and U0126 vs. control). Neurological testing and tetrazolium red staining were performed after 1 day. PBN decreased the infarct volume by 70% compared with the control (P<0.05) and a tendency towards reduced infarcts was seen in the PP2 or U0126 groups. Furthermore, neurological testing was consistent with the volumetric analysis. In conclusion, PBN appears to be a potential neuroprotective agent in hyperglycemic, focal ischemic brain injury, while the efficacy of PP2 and U0126 could not be confirmed by the present data.

Citing Articles

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S-nitrosylation of c-Src via NMDAR-nNOS module promotes c-Src activation and NR2A phosphorylation in cerebral ischemia/reperfusion.

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Neuroprotection by S-PBN in hyperglycemic ischemic brain injury in rats.

Molnar M, Lennmyr F Ups J Med Sci. 2010; 115(3):163-8.

PMID: 20636251 PMC: 2939516. DOI: 10.3109/03009734.2010.498592.

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