Oxidative Stress in Helicobacter Pylori-induced Gastric Cell Injury

Overview

Journal Inflammopharmacology

Specialty Pharmacology

Date 2005 Nov 2

PMID 16259728

Citations 14

Authors

Hyeyoung Kim

Affiliations

Soon will be listed here.

Abstract

Oxygen radicals are supposed to be involved in inflammation and cell proliferation. Helicobacter pylori induces decrease in antioxidant defense factors, such as GSH, mucus and constitutive nitric oxide (NO), gastric mucosal injury and inflammation. Inflammation and injury might be caused by oxidant-mediated expression of inflammatory cytokine interleukin-8 (IL-8) and inflammatory enzymes such as cyclooxtgenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), which were mediated by oxidant-sensitive transcription factors such as nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), possibly with mitogen activated protein kinase (MAPK) activation. H. pylori-induced alterations in protein expression demonstrate the involvement of oxidative stress in the pathogenesis of H. pylori-induced gastric diseases. The differentially expressed genes and proteins may be useful as prognostic indices for gastric diseases associated with H. pylori infection. In conclusion, oxygen radicals are produced in gastric epithelial cells infected with H. pylori, which may reduce the antioxidant defense mechanism and turn on the expression of inflammatory genes, adhesion molecules and mediators stimulating cell proliferation, as well as defensive molecular chaperones in gastric epithelial cells.

Citing Articles

A2BR facilitates the pathogenesis of H. pylori-associated GU by inducing oxidative stress through p38 MAPK phosphorylation.

Tang W, Guan M, Li Z, Pan W, Wang Z Heliyon. 2023; 9(11):e21004.

PMID: 38027590 PMC: 10660004. DOI: 10.1016/j.heliyon.2023.e21004.

Astaxanthin Inhibits Matrix Metalloproteinase Expression by Suppressing PI3K/AKT/mTOR Activation in -Infected Gastric Epithelial Cells.

Lee J, Lim J, Kim H Nutrients. 2022; 14(16).

PMID: 36014933 PMC: 9412703. DOI: 10.3390/nu14163427.

Korean Red Ginseng Extract Inhibits IL-8 Expression via Nrf2 Activation in -Infected Gastric Epithelial Cells.

Kim H, Lim J, Kim H Nutrients. 2022; 14(5).

PMID: 35268019 PMC: 8912635. DOI: 10.3390/nu14051044.

β-Carotene Inhibits Expression of Matrix Metalloproteinase-10 and Invasion in -Infected Gastric Epithelial Cells.

Bae S, Lim J, Kim H Molecules. 2021; 26(6).

PMID: 33809289 PMC: 8002206. DOI: 10.3390/molecules26061567.

Astaxanthin Inhibits Mitochondrial Dysfunction and Interleukin-8 Expression in -Infected Gastric Epithelial Cells.

Kim S, Lim J, Kim H Nutrients. 2018; 10(9).

PMID: 30231525 PMC: 6164770. DOI: 10.3390/nu10091320.

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