Platelets Mediate Cytotoxic T Lymphocyte-induced Liver Damage

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 2005 Nov 1

PMID 16258538

Citations 153

Authors

Matteo Iannacone

Giovanni Sitia

Masanori Isogawa

Patrizia Marchese

Maria G Castro

Pedro R Lowenstein

Francis V Chisari

Zaverio M Ruggeri

Luca G Guidotti

Affiliations

Soon will be listed here.

Abstract

We found that platelet depletion reduces intrahepatic accumulation of virus-specific cytotoxic T lymphocytes (CTLs) and organ damage in mouse models of acute viral hepatitis. Transfusion of normal but not activation-blocked platelets in platelet-depleted mice restored accumulation of CTLs and severity of disease. In contrast, anticoagulant treatment that prevented intrahepatic fibrin deposition without reducing platelet counts did not avert liver injury. Thus, activated platelets contribute to CTL-mediated liver immunopathology independently of procoagulant function.

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