The Antioxidant Anethole Dithiolethione Inhibits Monoamine Oxidase-B but Not Monoamine Oxidase A Activity in Extracts of Cultured Astrocytes

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2005 Oct 28

PMID 16252076

Citations 8

Authors

B Drukarch

J Flier

C A M Jongenelen

G Andringa

A N M Schoffelmeer

Affiliations

Soon will be listed here.

Abstract

Anethole dithiolethione (ADT) is a clinically available, pluripotent antioxidant proposed as a neuroprotectant for Parkinson's disease (PD). Here, using extracts from cultured astrocytes, containing both monoamine oxidase (MAO) A and B activity, we demonstrate that ADT concentration-dependently inhibits MAO-B activity in a clinically relevant concentration range (0.03-30 microM, IC-50 = 0.5 microM) without affecting MAO A activity. Considering the alleged contribution of MAO activity in general, and MAO-B in particular, to oxidative stress and neurodegeneration in PD, our data further support the neuroprotective potential of ADT.

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