Lipid-soluble 3-pyridinol Antioxidants Spare Alpha-tocopherol and Do Not Efficiently Mediate Peroxidation of Cholesterol Esters in Human Low-density Lipoprotein

Overview

Journal J Med Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2005 Oct 28

PMID 16250637

Citations 4

Authors

Hye-Young Kim

Derek A Pratt

Jennifer R Seal

Maikel Wijtmans

Ned A Porter

Affiliations

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Abstract

Because alpha-tocopherol (alpha-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density lipoprotein (LDL) in vitro and has displayed disappointing results against the onset and development of atherosclerosis, it may not be appropriate for use as a therapeutic in the prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare alpha-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human LDL.

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