An Overview of Drug Development with Special Emphasis on the Role of Visual Electrophysiological Testing

Overview

Journal Doc Ophthalmol

Specialty Ophthalmology

Date 2005 Oct 27

PMID 16249953

Citations 2

Authors

Mitchell Brigell

Cun-Jian Dong

Serge Rosolen

Radouil Tzekov

Affiliations

Soon will be listed here.

Abstract

Visual electrophysiological techniques, such as electroretinography (ERG) and visual evoked potentials (VEP) can provide useful information on the safety, efficacy, and proper dosing of chemical entities under development as new drug therapies. During post-marketing safety surveillance, a variety of visual electrophysiological measures can be used to objectively assess and document individual patient response to ophthalmic drugs and ocular or visual system side effects of non-ophthalmic drugs. In this paper, the discovery, exploratory development, full-development and post-marketing stages of drug development are briefly outlined. The potential role of visual electrophysiological techniques in each of these stages is described and discussed.

Citing Articles

Visual Electrodiagnostic Testing in Birdshot Chorioretinopathy.

Tzekov R, Madow B J Ophthalmol. 2015; 2015:680215.

PMID: 26246903 PMC: 4515528. DOI: 10.1155/2015/680215.

Effects of hypercapnia on the electroretinogram in sevoflurane and isoflurane anaesthetized dogs.

Varela Lopez O, Alvarez Vazquez J, Gonzalez Cantalapiedra A, Rosolen S Doc Ophthalmol. 2010; 121(1):9-20.

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