Discovery of a Biologically Active Thiostrepton Fragment

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2005 Oct 27

PMID 16248640

Citations 28

Authors

K C Nicolaou

Mark Zak

Shai Rahimipour

Anthony A Estrada

Sang Hyup Lee

Aurora OBrate

Paraskevi Giannakakou

M Reza Ghadiri

Affiliations

Soon will be listed here.

Abstract

Design, synthesis, and biological evaluation of several domains of the thiopeptide antibiotic thiostrepton led to the discovery of a biologically active fragment. The biological properties of this novel small organic molecule include antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VREF) bacterial strains, as well as cytotoxic action against a number of cancer cell lines.

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