T-cells in Neuronal Injury and Repair: Semaphorins and Related T-cell Signals

Overview

Journal Neuromolecular Med

Specialty Biochemistry

Date 2005 Oct 26

PMID 16247181

Citations 10

Authors

Pascale Giraudon

Peggy Vincent

Carine Vuaillat

Affiliations

Soon will be listed here.

Abstract

There are many parallels between the hematopoietic and the nervous systems in terms of mechanisms regulating their development and functions. In neuroinflammatory diseases, interaction between the immune and nervous systems through shared molecules is suspected to trigger an inappropriate crosstalk and lead to demyelination and axonal loss. Here we focus on semaphorins and their functions in the nervous and immune systems and point out the deleterious effect of an immune semaphorin, semaphorin 4D (Sema4D)/CD100, on oligodendrocyte integrity and survival. We propose immune semaphorins as new candidates involved in the pathogenic mechanisms of neuroinflammatory diseases, promoting demyelination, and impairing neuroregeneration.

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References

Raine C, Scheinberg L, WALTZ J . Multiple sclerosis. Oligodendrocyte survival and proliferation in an active established lesion. Lab Invest. 1981; 45(6):534-46. View

Pasterkamp R, Verhaagen J . Emerging roles for semaphorins in neural regeneration. Brain Res Brain Res Rev. 2001; 35(1):36-54. DOI: 10.1016/s0165-0173(00)00050-3. View

Chang A, Nishiyama A, Peterson J, Prineas J, Trapp B . NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J Neurosci. 2000; 20(17):6404-12. PMC: 6772992. View

Giraudon P, Szymocha R, Buart S, Bernard A, Cartier L, Belin M . T lymphocytes activated by persistent viral infection differentially modify the expression of metalloproteinases and their endogenous inhibitors, TIMPs, in human astrocytes: relevance to HTLV-I-induced neurological disease. J Immunol. 2000; 164(5):2718-27. DOI: 10.4049/jimmunol.164.5.2718. View

Sekido Y, Bader S, Latif F, Chen J, Duh F, Wei M . Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. Proc Natl Acad Sci U S A. 1996; 93(9):4120-5. PMC: 39497. DOI: 10.1073/pnas.93.9.4120. View

Deng W, Poretz R . Oligodendroglia in developmental neurotoxicity. Neurotoxicology. 2003; 24(2):161-78. DOI: 10.1016/S0161-813X(02)00196-1. View

Spassky N, de Castro F, Le Bras B, Heydon K, Bloch-Gallego E, Chedotal A . Directional guidance of oligodendroglial migration by class 3 semaphorins and netrin-1. J Neurosci. 2002; 22(14):5992-6004. PMC: 6757938. DOI: 20026573. View

de Wit J, Verhaagen J . Role of semaphorins in the adult nervous system. Prog Neurobiol. 2003; 71(2-3):249-67. DOI: 10.1016/j.pneurobio.2003.06.001. View

Jones L, Yamaguchi Y, Stallcup W, Tuszynski M . NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J Neurosci. 2002; 22(7):2792-803. PMC: 6758310. DOI: 20026258. View

10.

Moreau-Fauvarque C, Kumanogoh A, Camand E, Jaillard C, Barbin G, Boquet I . The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion. J Neurosci. 2003; 23(27):9229-39. PMC: 6740837. View

11.

Elhabazi A, Delaire S, Bensussan A, Boumsell L, Bismuth G . Biological activity of soluble CD100. I. The extracellular region of CD100 is released from the surface of T lymphocytes by regulated proteolysis. J Immunol. 2001; 166(7):4341-7. DOI: 10.4049/jimmunol.166.7.4341. View

12.

Kolodkin A, Matthes D, OConnor T, Patel N, Admon A, Bentley D . Fasciclin IV: sequence, expression, and function during growth cone guidance in the grasshopper embryo. Neuron. 1992; 9(5):831-45. DOI: 10.1016/0896-6273(92)90237-8. View

13.

Wu Q, Miller R, Ransohoff R, Robinson S, Bu J, Nishiyama A . Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci. 2000; 20(7):2609-17. PMC: 6772229. View

14.

Giraudon P, Buart S, Bernard A, Thomasset N, Belin M . Extracellular matrix-remodeling metalloproteinases and infection of the central nervous system with retrovirus human T-lymphotropic virus type I (HTLV-I). Prog Neurobiol. 1996; 49(2):169-84. DOI: 10.1016/0301-0082(96)00017-2. View

15.

Delaire S, Billard C, Tordjman R, Chedotal A, Elhabazi A, Bensussan A . Biological activity of soluble CD100. II. Soluble CD100, similarly to H-SemaIII, inhibits immune cell migration. J Immunol. 2001; 166(7):4348-54. DOI: 10.4049/jimmunol.166.7.4348. View

16.

Brambilla E, Constantin B, Drabkin H, Roche J . Semaphorin SEMA3F localization in malignant human lung and cell lines: A suggested role in cell adhesion and cell migration. Am J Pathol. 2000; 156(3):939-50. PMC: 1876858. DOI: 10.1016/S0002-9440(10)64962-0. View

17.

Levine J, Stincone F, Lee Y . Development and differentiation of glial precursor cells in the rat cerebellum. Glia. 1993; 7(4):307-21. DOI: 10.1002/glia.440070406. View

18.

Castellani V, Rougon G . Control of semaphorin signaling. Curr Opin Neurobiol. 2002; 12(5):532-41. DOI: 10.1016/s0959-4388(02)00357-4. View

19.

Dou C, Levine J . Inhibition of neurite growth by the NG2 chondroitin sulfate proteoglycan. J Neurosci. 1994; 14(12):7616-28. PMC: 6576915. View

20.

Raper J, Kapfhammer J . The enrichment of a neuronal growth cone collapsing activity from embryonic chick brain. Neuron. 1990; 4(1):21-9. DOI: 10.1016/0896-6273(90)90440-q. View