Amygdala Responsiveness is Modulated by Tryptophan Hydroxylase-2 Gene Variation

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2005 Oct 26

PMID 16245070

Citations 57

Authors

T Canli

E Congdon

L Gutknecht

R T Constable

K P Lesch

Affiliations

Soon will be listed here.

Abstract

The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.

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