» Articles » PMID: 16240136

Gastrointestinal Stromal Tumor in a Child and Review of the Literature

Overview
Date 2005 Oct 22
PMID 16240136
Citations 9
Authors
Affiliations
Soon will be listed here.
Abstract

Gastrointestinal stromal tumors (GIST) are c-KIT positive neoplasm that occur predominantly in adults. A 13-year-old boy who presented with massive gastrointestinal hemorrhage was subsequently diagnosed with GIST of the stomach. The tumor originated from the lesser curvature with a narrow base and no infiltration into surrounding organs. Two metastatic lesions in the liver were also found. Total excision of the gastric lesion was performed followed by adjuvant imatinib mesylate chemotherapy. He has had no signs of recurrence during 8 months of follow-up. GIST in children are rare and their behavior is notoriously difficult to predict. We report our experience and review the literature.

Citing Articles

Laparoscopic resection of a rare gastrointestinal stromal tumor in children.

Lima M, Gargano T, Ruggeri G, Pession A, Mariotto A, Maffi M Springerplus. 2015; 4:73.

PMID: 25717425 PMC: 4336300. DOI: 10.1186/s40064-015-0850-9.


Incidental GIST after appendectomy in a pediatric patient: a first instance and review of pediatric patients with CD117 confirmed GISTs.

Tran S, Dingeldein M, Mengshol S, Kay S, Chin A Pediatr Surg Int. 2013; 30(4):457-66.

PMID: 24292407 DOI: 10.1007/s00383-013-3432-3.


Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumors.

Belinsky M, Rink L, von Mehren M Front Oncol. 2013; 3:117.

PMID: 23730622 PMC: 3656383. DOI: 10.3389/fonc.2013.00117.


Gastrointestinal stromal tumor of the stomach in a child with a 3-year follow-up period-Case report.

Miranda M, Alberti L, Tatsuo E, Picarro C, Rausch M Int J Surg Case Rep. 2011; 2(6):114-7.

PMID: 22096700 PMC: 3199713. DOI: 10.1016/j.ijscr.2011.02.010.


A large gastrointestinal stromal tumor of the duodenum: a case report.

Morcos B, Al-Ahmad F J Med Case Rep. 2011; 5:457.

PMID: 21917160 PMC: 3180710. DOI: 10.1186/1752-1947-5-457.


References
1.
Miettinen M, Lasota J . Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch. 2001; 438(1):1-12. DOI: 10.1007/s004280000338. View

2.
DeMatteo R, Lewis J, Leung D, Mudan S, Woodruff J, Brennan M . Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg. 2000; 231(1):51-8. PMC: 1420965. DOI: 10.1097/00000658-200001000-00008. View

3.
Wu P, Langerman A, Ryan C, Hart J, Swiger S, Posner M . Surgical treatment of gastrointestinal stromal tumors in the imatinib (STI-571) era. Surgery. 2003; 134(4):656-65. DOI: 10.1016/s0039-6060(03)00314-3. View

4.
Pierie J, Choudry U, Muzikansky A, Yeap B, Souba W, Ott M . The effect of surgery and grade on outcome of gastrointestinal stromal tumors. Arch Surg. 2001; 136(4):383-9. DOI: 10.1001/archsurg.136.4.383. View

5.
Karnak I, Kale G, Tanyel F, Buyukpamukcu N . Malignant stromal tumor of the colon in an infant: diagnostic difficulties and differential diagnosis. J Pediatr Surg. 2003; 38(2):245-7. DOI: 10.1053/jpsu.2003.50054. View