Promoting Apoptosis As a Strategy for Cancer Drug Discovery

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2005 Oct 22

PMID 16239906

Citations 363

Authors

Stephen W Fesik

Affiliations

Soon will be listed here.

Abstract

Apoptosis is deregulated in many cancers, making it difficult to kill tumours. Drugs that restore the normal apoptotic pathways have the potential for effectively treating cancers that depend on aberrations of the apoptotic pathway to stay alive. Apoptosis targets that are currently being explored for cancer drug discovery include the tumour-necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors, the BCL2 family of anti-apoptotic proteins, inhibitor of apoptosis (IAP) proteins and MDM2.

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