Larvicidal Activity of Cybistax Antisyphilitica Against Aedes Aegypti Larvae

Overview

Journal Fitoterapia

Publisher Elsevier

Specialties Pharmacology
Rehabilitation Medicine

Date 2005 Oct 19

PMID 16229968

Citations 9

Authors

A M S Rodrigues

J E de Paula

F Roblot

A Fournet

L S Espindola

Affiliations

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Abstract

The larvicidal activity against Aedes aegypti larvae of a stem wood hexane extract of Cybistax antisyphilitica was evaluated. Bioassay-guided fractionation of the crude extract, monitored by larvicidal assay, led to the isolation of a natural quinone identified as 2-hydroxy-3-(3-methyl-2-butenyl)-1.4-naphthoquinone (lapachol). This compound was quite potent against A. aegypti larvae (LC50 26.3 microg/ml).

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