Extending a Spectrin Repeat Unit. I: Linear Force-extension Response

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 2005 Oct 18

PMID 16227506

Citations 12

Authors

Sterling Paramore

Gary S Ayton

Dina T Mirijanian

Gregory A Voth

Affiliations

Soon will be listed here.

Abstract

Nonequilibrium molecular dynamics simulations were used to calculate the elastic properties of a spectrin repeat unit. A contiguous alpha-helical linker was constructed by employing periodic boundary conditions, allowing a novel scheme for evaluating the thermodynamic force as a function of extension. By measuring the force-extension response under small extensions, spectrin was observed to behave primarily as an elastic material with a spring constant of 1700 +/- 100 pN/nm. The implications of this spring constant, in terms of the properties of the spectrin tetramer, are also discussed.

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