The HIV Infection and Immune Activation: "to Fight and Burn"

Overview

Journal Curr Infect Dis Rep

Specialty Infectious Diseases

Date 2005 Oct 18

PMID 16225786

Citations 9

Authors

Victor Appay

Francois Boutboul

Brigitte Autran

Affiliations

Soon will be listed here.

Abstract

Immune activation, a normal immune reaction to pathogens, is now recognized as a major driving force of the CD4 T-cell depletion and immune disorders caused by HIV. By contrast, the natural hosts of its ancestor virus, simian immunodeficiency virus, have adapted to this virus by blocking immune activation and remaining healthy. This review will focus on evidence demonstrating how immune activation associated with HIV infection exhausts immune defenses to HIV as well as the immune system, thus leading to immunosenescence and immunodeficiency, and how treatment can disrupt this vicious and ultimately fatal circle.

Citing Articles

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