A New Approach to Understand the Pathophysiology of Parkinson's Disease

Overview

Journal J Neurol

Specialty Neurology

Date 2005 Oct 14

PMID 16222431

Citations 29

Authors

Atsushi Nambu

Affiliations

Soon will be listed here.

Abstract

Here I introduce a dynamic model of the basal ganglia functions for the control of voluntary movement: information through major pathways in the cortico-basal ganglia loop, i. e., the cortico-STN-GPi/SNr "hyperdirect", cortico-striato-GPi/SNr "direct" and cortico-striato-GPe-STN-GPi/SNr "indirect" pathways, dynamically controls the activity of the thalamus and cortex and releases only the selected motor program at the selected timing. Based on the dynamic model, the pathophysiology of Parkinson's disease and the mechanism for the effectiveness of stereotaxic surgery can better be explained by an increase or decrease of disinhibition and inhibition in the thalamus and cortex in the temporal and spatial domains.

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