Organocatalytic Asymmetric Michael Addition of 2,4-pentandione to Nitroolefins

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2005 Oct 8

PMID 16209517

Citations 9

Authors

Jian Wang

Hao Li

Wenhu Duan

Liansuo Zu

Wei Wang

Affiliations

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Abstract

[reaction: see text] A novel binaphthyl-derived amine thiourea organocatalyst has been developed and demonstrated to efficiently catalyze Michael addition reactions (using as low as 1 mol % loading) of diketones to nitroalkenes with remarkably high enantioselectivities.

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