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Development of Daptomycin Resistance in Vivo in Methicillin-resistant Staphylococcus Aureus

Overview
Journal J Clin Microbiol
Specialty Microbiology
Date 2005 Oct 7
PMID 16207998
Citations 86
Authors
M K Hayden
K Rezai
R A Hayes
K Lolans
J P Quinn
R A Weinstein
Affiliations
Soon will be listed here.
Abstract

Daptomycin is a new lipopeptide antibiotic that is rapidly bactericidal against Staphylococcus aureus. We report daptomycin resistance and treatment failure in 2 patients with osteomyelitis due to methicillin-resistant S. aureus. Disk diffusion susceptibility testing failed to detect resistance. Daptomycin at high concentration retained bactericidal activity against resistant isolates.

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