Indole-3-acetic Acid Antagonists of the Prostaglandin D2 Receptor CRTH2

Overview

Journal J Med Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2005 Sep 30

PMID 16190744

Citations 9

Authors

Richard E Armer

Mark R Ashton

Edward A Boyd

Chris J Brennan

Frederick A Brookfield

Lucien Gazi

Shan L Gyles

Philip A Hay

Michael G Hunter

David Middlemiss

Mark Whittaker

Luzheng Xue

Roy Pettipher

Affiliations

Soon will be listed here.

Abstract

Prostaglandin D2 (PGD2) acting at the CRTH2 receptor (chemoattractant receptor-homologous molecule expressed on Th2 cells) has been linked with a variety of allergic and other inflammatory diseases. We describe a family of indole-1-sulfonyl-3-acetic acids that are potent and selective CRTH2 antagonists that possess good oral bioavailability. The compounds may serve as novel starting points for the development of treatments of inflammatory disease such as asthma, allergic rhinitis, and atopic dermatitis.

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