Resetting the Functional Capacity of Regulatory T Cells: a Novel Immunotherapeutic Strategy to Promote Immune Tolerance
Overview
Pharmacology
Authors
Affiliations
Over the last few years, there has been a re-emergence of the concept of suppressor/regulatory T cells among the central players of immune mechanisms controlling a wide variety of immune responses from physiological autoreactivity (i.e., response to self-antigens) to responses to transplants, tumours and infectious antigens. Regulatory T cells are diverse in their phenotypes, antigen specificity, mode of action and immunopathological relevance. This review briefly summarises studies from the authors' group showing that specialised subsets of regulatory T cells are instrumental in the control of autoimmune diseases and more specifically of Type 1 diabetes. In addition, this review will provide evidence supporting the notion that CD3-specific monoclonal antibodies are representatives of a new category of immunotherapeutic agents that possess the unique capacity to promote immunological tolerance (an antigen-specific unresponsiveness in the absence of long-term generalised immunosuppression) through their ability to induce immunoregulatory T cells.
Jorns A, Akin M, Arndt T, Terbish T, Zu Vilsendorf A, Wedekind D J Mol Med (Berl). 2014; 92(7):743-55.
PMID: 24599515 DOI: 10.1007/s00109-014-1137-2.
Zhao Y, Lin B, Darflinger R, Zhang Y, Holterman M, Skidgel R PLoS One. 2009; 4(1):e4226.
PMID: 19156219 PMC: 2627485. DOI: 10.1371/journal.pone.0004226.