Hierarchical Metabolomics Demonstrates Substantial Compositional Similarity Between Genetically Modified and Conventional Potato Crops

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2005 Sep 28

PMID 16186495

Citations 77

Authors

Gareth S Catchpole

Manfred Beckmann

David P Enot

Madhav Mondhe

Britta Zywicki

Janet Taylor

Nigel Hardy

Aileen Smith

Ross D King

Douglas B Kell

Oliver Fiehn

John Draper

Affiliations

Soon will be listed here.

Abstract

There is current debate whether genetically modified (GM) plants might contain unexpected, potentially undesirable changes in overall metabolite composition. However, appropriate analytical technology and acceptable metrics of compositional similarity require development. We describe a comprehensive comparison of total metabolites in field-grown GM and conventional potato tubers using a hierarchical approach initiating with rapid metabolome "fingerprinting" to guide more detailed profiling of metabolites where significant differences are suspected. Central to this strategy are data analysis procedures able to generate validated, reproducible metrics of comparison from complex metabolome data. We show that, apart from targeted changes, these GM potatoes in this study appear substantially equivalent to traditional cultivars.

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