» Articles » PMID: 16185345

Flow-induced Platelet Activation in a St. Jude Mechanical Heart Valve, a Trileaflet Polymeric Heart Valve, and a St. Jude Tissue Valve

Overview
Journal Artif Organs
Date 2005 Sep 28
PMID 16185345
Citations 16
Authors
Affiliations
Soon will be listed here.
Abstract

Polymer heart valves have been under investigation since the 1960s, but their success has been hampered by an overall lack of durability mainly due to calcification of the leaflets and a relatively high rate of thromboembolic complications. A new polymer (Quatromer) trileaflet design was tested for its thrombogenic potential and was compared to that of existing prosthetic heart valves routinely implanted in patients: a St. Jude Medical bileaflet mechanical heart valve (MHV) and a St. Jude porcine bioprosthetic tissue valve. The valves were mounted in a left ventricular assist device and the procoagulant activity of the platelets was measured using a platelet activation state (PAS) assay. The PAS measurements indicated that the platelet activation level induced by the polymeric valve was very similar to that induced by the St. Jude Medical MHV and the St. Jude tissue valve. No significant difference was observed between the three valves, indicating that they have a comparable thrombogenic potential.

Citing Articles

A Fibrin-Thrombin Based In Vitro Perfusion System to Study Flow-Related Prosthetic Heart Valves Thrombosis.

Kreinin Y, Talmon Y, Levi M, Khoury M, Or I, Raad M Ann Biomed Eng. 2024; 52(6):1665-1677.

PMID: 38459196 PMC: 11082030. DOI: 10.1007/s10439-024-03480-6.


Simulation of Mechanical Heart Valve Dysfunction and the Non-Newtonian Blood Model Approach.

Chen A, Basri A, Ismail N, Tamagawa M, Zhu D, Ahmad K Appl Bionics Biomech. 2022; 2022:9612296.

PMID: 35498142 PMC: 9042627. DOI: 10.1155/2022/9612296.


Visions of TAVR Future: Development and Optimization of a Second Generation Novel Polymeric TAVR.

Kovarovic B, Helbock R, Baylous K, Rotman O, Slepian M, Bluestein D J Biomech Eng. 2022; 144(6).

PMID: 35318480 PMC: 8990719. DOI: 10.1115/1.4054149.


Paradoxical Effect of Nonphysiological Shear Stress on Platelets and von Willebrand Factor.

Chen Z, Mondal N, Ding J, Koenig S, Slaughter M, Wu Z Artif Organs. 2015; 40(7):659-68.

PMID: 26582038 PMC: 4871771. DOI: 10.1111/aor.12606.


Hemodynamic and thrombogenic analysis of a trileaflet polymeric valve using a fluid-structure interaction approach.

Piatti F, Sturla F, Marom G, Sheriff J, Claiborne T, Slepian M J Biomech. 2015; 48(13):3641-9.

PMID: 26329461 PMC: 4600671. DOI: 10.1016/j.jbiomech.2015.08.009.