Noise in Gene Expression: Origins, Consequences, and Control

Overview

Journal Science

Specialty Science

Date 2005 Sep 24

PMID 16179466

Citations 677

Authors

Jonathan M Raser

Erin K OShea

Affiliations

Soon will be listed here.

Abstract

Genetically identical cells and organisms exhibit remarkable diversity even when they have identical histories of environmental exposure. Noise, or variation, in the process of gene expression may contribute to this phenotypic variability. Recent studies suggest that this noise has multiple sources, including the stochastic or inherently random nature of the biochemical reactions of gene expression. In this review, we summarize noise terminology and comment on recent investigations into the sources, consequences, and control of noise in gene expression.

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