Reference Charts for the Relationships Between Dual-energy X-ray Absorptiometry-assessed Bone Mineral Content and Lean Mass in 3,063 Healthy Men and Premenopausal and Postmenopausal Women

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2005 Sep 21

PMID 16172799

Citations 10

Authors

Carlos Cure-Cure

Ricardo F Capozza

Gustavo R Cointry

Margarita Meta

Pablo Cure-Ramirez

Jose L Ferretti

Affiliations

Soon will be listed here.

Abstract

Correlations between dual-energy X-ray absorptiometry (DXA)-assessed bone mineral content and lean mass (BMC-LM curves), and between BMC/LM ratio and age ([BMC/LM]-age curves), were analyzed in the whole body (WB), the upper limbs (ULs) and the lower limbs (LLs) of 3,063 healthy Hispanic adults. Groups of 472 men aged 25-87 years, 1,035 premenopausal (pre-MP) women aged 27-54 years, and 1,556 post-menopausal (post-MP) women aged 48-93 years were studied with a GE-Lunar DPX-Plus device. BMC-LM curves confirmed previous observations that BMC and LM masses always correlate linearly, with similar slopes within each region, but differing in intercepts according to gender and hormonal status. Multiple regression tests showed little or no independent interaction of body weight or height with those relationships. [BMC/LM]-age curves were flat in men but showed the positive influence of estrogens throughout the age range in women. Z-scored graphs of all the corresponding relationships were compiled, showing the confidence intervals for means +/-1, +/-2, and +/-3 SDs of the data (+/-1, +/-2, +/-3 z-scores) along BMC-LM and [BMC/LM]-age curves. These charts are proposed as references for assessing how well bone mass (as assessed by BMC) and muscle mass (assumed proportional to LM) follow the natural anthropometric/biomechanical proportionality in Hispanic men and women within the age range studied, employing similar devices. Charts for LLs, showing the lowest variance amongst the studied correlations and approaching the origin as an exclusive feature, could provide the most accurate reference curves. Differences between data from ULs and LLs may provide information about any eventual interaction of body-weight bearing with the general results. The proposed analysis may provide useful information for approaching a differential diagnosis between disuse-related and other types of osteopenias employing only DXA.

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References

Bachrach L, Hastie T, Wang M, Narasimhan B, Marcus R . Bone mineral acquisition in healthy Asian, Hispanic, black, and Caucasian youth: a longitudinal study. J Clin Endocrinol Metab. 1999; 84(12):4702-12. DOI: 10.1210/jcem.84.12.6182. View

Bassey E, Rothwell M, Littlewood J, PYE D . Pre- and postmenopausal women have different bone mineral density responses to the same high-impact exercise. J Bone Miner Res. 1998; 13(12):1805-13. DOI: 10.1359/jbmr.1998.13.12.1805. View

Compston J, Bhambhani M, Laskey M, Murphy S, Khaw K . Body composition and bone mass in post-menopausal women. Clin Endocrinol (Oxf). 1992; 37(5):426-31. DOI: 10.1111/j.1365-2265.1992.tb02354.x. View

Capozza R, Cointry G, Cure-Ramirez P, Ferretti J, Cure-Cure C . A DXA study of muscle-bone relationships in the whole body and limbs of 2512 normal men and pre- and post-menopausal women. Bone. 2004; 35(1):283-95. DOI: 10.1016/j.bone.2004.03.010. View

Tothill P, Laskey M, Orphanidou C, van Wijk M . Anomalies in dual energy X-ray absorptiometry measurements of total-body bone mineral during weight change using Lunar, Hologic and Norland instruments. Br J Radiol. 2000; 72(859):661-9. DOI: 10.1259/bjr.72.859.10624323. View

Khosla S, Atkinson E, Riggs B, Melton 3rd L . Relationship between body composition and bone mass in women. J Bone Miner Res. 1996; 11(6):857-63. DOI: 10.1002/jbmr.5650110618. View

Reid I . Relationships among body mass, its components, and bone. Bone. 2002; 31(5):547-55. DOI: 10.1016/s8756-3282(02)00864-5. View

Ferretti J, Capozza R, Cointry G, Garcia S, Plotkin H, Alvarez Filgueira M . Gender-related differences in the relationship between densitometric values of whole-body bone mineral content and lean body mass in humans between 2 and 87 years of age. Bone. 1998; 22(6):683-90. DOI: 10.1016/s8756-3282(98)00046-5. View

Chen Z, Lohman T, Stini W, Ritenbaugh C, Aickin M . Fat or lean tissue mass: which one is the major determinant of bone mineral mass in healthy postmenopausal women?. J Bone Miner Res. 1997; 12(1):144-51. DOI: 10.1359/jbmr.1997.12.1.144. View

10.

Lanyon L, Rubin C . Static vs dynamic loads as an influence on bone remodelling. J Biomech. 1984; 17(12):897-905. DOI: 10.1016/0021-9290(84)90003-4. View

11.

Cointry G, Capozza R, Negri A, Roldan E, Ferretti J . Biomechanical background for a noninvasive assessment of bone strength and muscle-bone interactions. J Musculoskelet Neuronal Interact. 2004; 4(1):1-11. View

12.

Visser M, Fuerst T, Lang T, SALAMONE L, Harris T . Validity of fan-beam dual-energy X-ray absorptiometry for measuring fat-free mass and leg muscle mass. Health, Aging, and Body Composition Study--Dual-Energy X-ray Absorptiometry and Body Composition Working Group. J Appl Physiol (1985). 1999; 87(4):1513-20. DOI: 10.1152/jappl.1999.87.4.1513. View

13.

Westerlind K, Wronski T, Ritman E, Luo Z, An K, Bell N . Estrogen regulates the rate of bone turnover but bone balance in ovariectomized rats is modulated by prevailing mechanical strain. Proc Natl Acad Sci U S A. 1997; 94(8):4199-204. PMC: 20601. DOI: 10.1073/pnas.94.8.4199. View

14.

Ferretti J, Cointry G, Capozza R, Frost H . Bone mass, bone strength, muscle-bone interactions, osteopenias and osteoporoses. Mech Ageing Dev. 2003; 124(3):269-79. DOI: 10.1016/s0047-6374(02)00194-x. View

15.

Villa M, Marcus R, Ramirez Delay R, Kelsey J . Factors contributing to skeletal health of postmenopausal Mexican-American women. J Bone Miner Res. 1995; 10(8):1233-42. DOI: 10.1002/jbmr.5650100814. View

16.

Pluijm S, Visser M, Smit J, Popp-Snijders C, Roos J, Lips P . Determinants of bone mineral density in older men and women: body composition as mediator. J Bone Miner Res. 2001; 16(11):2142-51. DOI: 10.1359/jbmr.2001.16.11.2142. View

17.

Mittlmeier T, Mattheck C, Dietrich F . Effects of mechanical loading on the profile of human femoral diaphyseal geometry. Med Eng Phys. 1994; 16(1):75-81. DOI: 10.1016/1350-4533(94)90014-0. View

18.

Leblanc A, Lin C, Shackelford L, Sinitsyn V, Evans H, Belichenko O . Muscle volume, MRI relaxation times (T2), and body composition after spaceflight. J Appl Physiol (1985). 2000; 89(6):2158-64. DOI: 10.1152/jappl.2000.89.6.2158. View

19.

Kanis J, Melton 3rd L, Christiansen C, JOHNSTON C, Khaltaev N . The diagnosis of osteoporosis. J Bone Miner Res. 1994; 9(8):1137-41. DOI: 10.1002/jbmr.5650090802. View

20.

Myburgh K, Charette S, Zhou L, Steele C, Arnaud S, Marcus R . Influence of recreational activity and muscle strength on ulnar bending stiffness in men. Med Sci Sports Exerc. 1993; 25(5):592-6. View