Recruitment of Dendritic Cells to Pathological Niches in Inflamed Liver

Overview

Journal Med Mol Morphol

Publisher Springer

Specialties Cell Biology
Molecular Biology
Pathology

Date 2005 Sep 20

PMID 16170461

Citations 17

Authors

Hiroyuki Yoneyama

Takafumi Ichida

Affiliations

Soon will be listed here.

Abstract

The liver is a specialized organ for host defense and immunity. Recruitment of dendritic cells (DCs) is crucial to host defense in a granulomatous liver disease in mice. In response to danger signals, DC precursors are mobilized de novo into the circulation. Myeloid DC (mDC) precursors are recruited to perisinusoidal spaces and activated to form granulomas. Recruited mDCs subsequently extravasate into Disse's space and migrate to the portal area to induce portal tract-associated lymphoid tissue (PALT). Some mDCs are remobilized into draining hepatic lymph nodes (LNs) to prime antigen-specific CD4+ helper T cells. Kupffer cell-derived CCL3/MIP-1alpha attracts mDC precursors to the sinusoidal granulomas, whereas PALT composed cell-derived CCL21/SLC attracts activated mDCs to the T-cell zone of PALT. Inflammatory cytokines modulate this sinusoid-portal migration through IL-1R/TLR signaling. Recruited mDCs themselves also produce several chemokines and cytokines that modulate T-cell responses. A unique trafficking of circulating mDC precursors within the inflammation-associated, newly formed compartments ("pathological niches") is strictly regulated by both homeostatic and inducible chemokines and determines the final efficiency of the immunity in this organ.

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References

Matsuno K, Nomiyama H, Yoneyama H, Uwatoku R . Kupffer cell-mediated recruitment of dendritic cells to the liver crucial for a host defense. Dev Immunol. 2003; 9(3):143-9. PMC: 2276107. DOI: 10.1080/1044667031000137610. View

Martin-Fontecha A, Sebastiani S, Hopken U, Uguccioni M, Lipp M, Lanzavecchia A . Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J Exp Med. 2003; 198(4):615-21. PMC: 2194169. DOI: 10.1084/jem.20030448. View

Tsuji N, Kawada N, Ikeda K, Kinoshita H, Kaneda K . Immunohistochemical and ultrastructural analyses of in situ activation of hepatic stellate cells around Propionibacterium acnes-induced granulomas in the rat liver. J Submicrosc Cytol Pathol. 1997; 29(1):125-33. View

Carbone F, Heath W . The role of dendritic cell subsets in immunity to viruses. Curr Opin Immunol. 2003; 15(4):416-20. DOI: 10.1016/s0952-7915(03)00074-8. View

David H, Reinke P . The concept of the "perisinusoidal functional unit" of the liver--importance to pathological processes. Exp Pathol. 1987; 32(4):193-224. DOI: 10.1016/s0232-1513(87)80031-2. View

Matsuno K, Ezaki T . Dendritic cell dynamics in the liver and hepatic lymph. Int Rev Cytol. 2000; 197:83-136. DOI: 10.1016/s0074-7696(00)97003-7. View

Nakatani K, Kaneda K, Seki S, Nakajima Y . Pit cells as liver-associated natural killer cells: morphology and function. Med Electron Microsc. 2004; 37(1):29-36. DOI: 10.1007/s00795-003-0229-9. View

Yoneyama H, Harada A, Imai T, Baba M, Yoshie O, Zhang Y . Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice. J Clin Invest. 1998; 102(11):1933-41. PMC: 509145. DOI: 10.1172/JCI4619. View

Kudo S, Matsuno K, Ezaki T, Ogawa M . A novel migration pathway for rat dendritic cells from the blood: hepatic sinusoids-lymph translocation. J Exp Med. 1997; 185(4):777-84. PMC: 2311511. DOI: 10.1084/jem.185.4.777. View

10.

Iizasa H, Yoneyama H, Mukaida N, Katakoka Y, Naito M, Yoshida N . Exacerbation of granuloma formation in IL-1 receptor antagonist-deficient mice with impaired dendritic cell maturation associated with Th2 cytokine production. J Immunol. 2005; 174(6):3273-80. DOI: 10.4049/jimmunol.174.6.3273. View

11.

Fujioka N, Mukaida N, Harada A, Akiyama M, Kasahara T, Kuno K . Preparation of specific antibodies against murine IL-1ra and the establishment of IL-1ra as an endogenous regulator of bacteria-induced fulminant hepatitis in mice. J Leukoc Biol. 1995; 58(1):90-8. DOI: 10.1002/jlb.58.1.90. View

12.

Naito M, Hasegawa G, Ebe Y, Yamamoto T . Differentiation and function of Kupffer cells. Med Electron Microsc. 2004; 37(1):16-28. DOI: 10.1007/s00795-003-0228-x. View

13.

Senoo H . Structure and function of hepatic stellate cells. Med Electron Microsc. 2004; 37(1):3-15. DOI: 10.1007/s00795-003-0230-3. View

14.

Sato T, Yamamoto H, Sasaki C, Wake K . Maturation of rat dendritic cells during intrahepatic translocation evaluated using monoclonal antibodies and electron microscopy. Cell Tissue Res. 1998; 294(3):503-14. DOI: 10.1007/s004410051201. View

15.

Ogata M, Zhang Y, Wang Y, Itakura M, Zhang Y, Harada A . Chemotactic response toward chemokines and its regulation by transforming growth factor-beta1 of murine bone marrow hematopoietic progenitor cell-derived different subset of dendritic cells. Blood. 1999; 93(10):3225-32. View

16.

Yoneyama H, Matsuno K, Zhang Y, Nishiwaki T, Kitabatake M, Ueha S . Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules. Int Immunol. 2004; 16(7):915-28. DOI: 10.1093/intimm/dxh093. View

17.

Matsuno K, Ezaki T, Kudo S, Uehara Y . A life stage of particle-laden rat dendritic cells in vivo: their terminal division, active phagocytosis, and translocation from the liver to the draining lymph. J Exp Med. 1996; 183(4):1865-78. PMC: 2192479. DOI: 10.1084/jem.183.4.1865. View

18.

Yoneyama H, Matsuno K, Zhang Y, Murai M, Itakura M, Ishikawa S . Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue, in a granulomatous liver disease. J Exp Med. 2001; 193(1):35-49. PMC: 2195882. DOI: 10.1084/jem.193.1.35. View

19.

Banchereau J, Steinman R . Dendritic cells and the control of immunity. Nature. 1998; 392(6673):245-52. DOI: 10.1038/32588. View

20.

Yoneyama H, Narumi S, Zhang Y, Murai M, Baggiolini M, Lanzavecchia A . Pivotal role of dendritic cell-derived CXCL10 in the retention of T helper cell 1 lymphocytes in secondary lymph nodes. J Exp Med. 2002; 195(10):1257-66. PMC: 2193754. DOI: 10.1084/jem.20011983. View