Infectious Agents Associated with Epizootic Rabbit Enteropathy: Isolation and Attempts to Reproduce the Syndrome

Overview

Journal Vet J

Specialty Veterinary Medicine

Date 2005 Sep 13

PMID 16154367

Citations 11

Authors

D Marlier

R Dewree

C Lassence

D Licois

J Mainil

P Coudert

L Meulemans

R Ducatelle

H Vindevogel

Affiliations

Soon will be listed here.

Abstract

Epizootic rabbit enteropathy (ERE), a highly lethal (30-80% mortality) disease of broiler rabbits aged 6-14 weeks, first appeared in 1997 in French intensive enclosed rabbitries and is of unknown aetiology. Bacteriological, virological and parasitical examination of the intestinal contents of rabbits that had died either in spontaneous field cases or after experimental reproduction of ERE, were undertaken in an attempt to identify infectious agents that may play a role in the disease. Two bacterial strains, Clostridium perfringens and non-enteropathogenic Escherichia coli were repeatedly isolated at high faecal counts from naturally infected animals. In field cases, a correlation between typical gross lesions of epizootic enteropathy and the presence of the alpha toxin of Cl. perfringens was observed (P<0.0001; Chi-squared test). Although attempts to reproduce the disease by inoculation with different pools of cultivable bacterial strains failed, the disease was successfully reproduced by inoculation with one French and two Belgian samples of caecal contents.

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