Coincidence Detection in Phosphoinositide Signaling

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2005 Sep 6

PMID 16139503

Citations 93

Authors

Jez G Carlton

Peter J Cullen

Affiliations

Soon will be listed here.

Abstract

Phosphoinositide lipids function as both signaling molecules and as compartment-specific localization signals for phosphoinositide-binding proteins. In recent years, both phosphoinositides and phosphoinositide-binding proteins have been reported to display a restricted, rather than a uniform, distribution across intracellular membranes. Here, we examine recent data documenting the restricted distribution of both phosphoinositides and phosphoinositide-binding proteins and examine how phosphoinositide-binding proteins might engage multiple binding partners to achieve these restricted localizations, effectively acting as detectors of coincident localization signals.

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