Fetal Cord Blood: Aspects of Heightened Immune Responses

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 2005 Sep 1

PMID 16133989

Citations 14

Authors

B Schaub

K G Tantisira

F K Gibbons

H He

A A Litonjua

M W Gillman

S Weiss

D L Perkins

D R Gold

P W Finn

Affiliations

Soon will be listed here.

Abstract

Neonatal immune responses have been associated with the development of atopy in childhood. We assessed in cord blood mononuclear cells (CBMC) whether increased allergen/mitogen-induced lymphoproliferation (LP) is associated with pro-allergic Th2 cytokine IL-13 or Th1 cytokine IFN-gamma secretion. We determined whether LP to one allergen is related to heightened lymphocyte function to other allergens/mitogen. CBMC from 135 neonates were stimulated with house dust mite (Derf1), cockroach, ovalbumin, or mitogen. LP to one allergen was associated with significantly increased LP to other allergens/mitogen. Increased Derf1-LP was associated with increased Derf1-induced IL-13 secretion (r = 0.21, p = 0.01). After adjusting for neonatal gender, race, and maternal smoking, Derf1-LP remained associated with Derf1-IL-13 (OR 3.08, 95% CI 1.56-6.10). Increased mitogen-induced proliferation was associated with increased mitogen-induced IL-13 secretion (r = 0.37, p < 0.001). For some individuals, a predisposition to a heightened immune response is already evident at birth. Whether this phenotype results in atopy in childhood warrants further investigation.

Citing Articles

Prenatal blood metals, per- and polyfluoroalkyl substances and antigen- or mitogen-stimulated cord blood lymphocyte proliferation and cytokine secretion.

Smith A, Lin P, Rifas-Shiman S, Fleisch A, Wright R, Coull B Environ Res. 2024; 259:119555.

PMID: 38964580 PMC: 11365774. DOI: 10.1016/j.envres.2024.119555.

BORN TO WHEEZE OR LEARNED WHEN WE WERE YOUNG: MATERNAL AND ENVIRONMENTAL FACTORS INFLUENCE ATOPIC RISK.

Finn P, Perkins D Trans Am Clin Climatol Assoc. 2023; 133:181-192.

PMID: 37701609 PMC: 10493753.

Perinatal granulopoiesis and risk of pediatric asthma.

Turturice B, Theorell J, Koenig M, Tussing-Humphreys L, Gold D, Litonjua A Elife. 2021; 10.

PMID: 33565964 PMC: 7889076. DOI: 10.7554/eLife.63745.

Prenatal Maternal Depression and Neonatal Immune Responses.

Hahn J, Gold D, Coull B, McCormick M, Finn P, Perkins D Psychosom Med. 2019; 81(4):320-327.

PMID: 31048634 PMC: 6501810. DOI: 10.1097/PSY.0000000000000686.

Perinatal Bacterial Exposure Contributes to IL-13 Aeroallergen Response.

Turturice B, Ranjan R, Nguyen B, Hughes L, Andropolis K, Gold D Am J Respir Cell Mol Biol. 2017; 57(4):419-427.

PMID: 28443674 PMC: 5650087. DOI: 10.1165/rcmb.2017-0027OC.

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