A Flavonoid from Medicinal Plants Blocks Hepatitis B Virus-e Antigen Secretion in HBV-infected Hepatocytes

Overview

Journal Antiviral Res

Publisher Elsevier

Date 2005 Aug 25

PMID 16118024

Citations 30

Authors

Min Soo Shin

Eun Hwa Kang

Young Ik Lee

Affiliations

Soon will be listed here.

Abstract

A flavonoid molecule that showed a unique anti-HBV function was isolated from Phyllanthus urinaria. The molecular formula was determined as C14H6O8 based on FAM-MS analysis and the structure was determined by NMR. The identified flavonoid molecule, ellagic acid, showed unique anti-HBV functions. Ellagic acid did not inhibit either HBV polymerase activity, HBV replication or block HBsAg secretion. Rather, ellagic acid blocks effectively HBeAg secretion in HepG2 2.2.15 cells (IC50=0.07 microg/ml). Since HBeAg is involved in immune tolerance during HBV infection, ellagic acid, a newly identified functional anti-HBV compound, may be a new candidate therapeutic against immune tolerance in HBV-infected individuals.

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