Role of Toll-like Receptor 4 in the Proinflammatory Response to Vibrio Cholerae O1 El Tor Strains Deficient in Production of Cholera Toxin and Accessory Toxins

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2005 Aug 23

PMID 16113340

Citations 10

Authors

G Kenneth Haines 3rd

Blayne Amir Sayed

Melissa S Rohrer

Verena Olivier

Karla J Fullner Satchell

Affiliations

Soon will be listed here.

Abstract

Following intranasal inoculation, Vibrio cholerae KFV101 (DeltactxAB DeltahapA DeltahlyA DeltartxA) colonizes and stimulates tumor necrosis factor alpha and interleukin 1beta (IL-1beta) in mice, similar to what occurs with isogenic strain P4 (DeltactxAB), but is less virulent and stimulates reduced levels of IL-6, demonstrating a role for accessory toxins in pathogenesis. Morbidity is enhanced in C3H/HeJ mice, indicating that Toll-like receptor 4 is important for infection containment.

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References

Sansonetti P, Phalipon A, Arondel J, Thirumalai K, Banerjee S, Akira S . Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation. Immunity. 2000; 12(5):581-90. DOI: 10.1016/s1074-7613(00)80209-5. View

Dhar R, GHAFOOR M, Nasralah A . Unusual non-serogroup O1 Vibrio cholerae bacteremia associated with liver disease. J Clin Microbiol. 1989; 27(12):2853-5. PMC: 267142. DOI: 10.1128/jcm.27.12.2853-2855.1989. View

Bubshait SA , Qadri M, Fontaine R, Cameron D . Seasonal, nontoxigenic Vibrio cholerae O1 Ogawa infections in the Eastern Region of Saudi Arabia. Int J Infect Dis. 2001; 4(4):198-202. DOI: 10.1016/s1201-9712(00)90109-7. View

Qadri F, Raqib R, Ahmed F, Rahman T, Wenneras C, Das S . Increased levels of inflammatory mediators in children and adults infected with Vibrio cholerae O1 and O139. Clin Diagn Lab Immunol. 2002; 9(2):221-9. PMC: 119937. DOI: 10.1128/cdli.9.2.221-229.2002. View

Fullner K, Boucher J, Hanes M, Haines 3rd G, Meehan B, Walchle C . The contribution of accessory toxins of Vibrio cholerae O1 El Tor to the proinflammatory response in a murine pulmonary cholera model. J Exp Med. 2002; 195(11):1455-62. PMC: 2193536. DOI: 10.1084/jem.20020318. View

Chen P, Li J, Barnes J, Kokkonen G, Lee J, Liu Y . Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. J Immunol. 2002; 169(11):6408-16. DOI: 10.4049/jimmunol.169.11.6408. View

Ortega-Cava C, Ishihara S, Rumi M, Kawashima K, Ishimura N, Kazumori H . Strategic compartmentalization of Toll-like receptor 4 in the mouse gut. J Immunol. 2003; 170(8):3977-85. DOI: 10.4049/jimmunol.170.8.3977. View

Morris Jr J . Cholera and other types of vibriosis: a story of human pandemics and oysters on the half shell. Clin Infect Dis. 2003; 37(2):272-80. DOI: 10.1086/375600. View

Satchell K . Activation and suppression of the proinflammatory immune response by Vibrio cholerae toxins. Microbes Infect. 2003; 5(13):1241-7. DOI: 10.1016/j.micinf.2003.08.007. View

10.

Cersini A, Martino M, Martini I, Rossi G, Bernardini M . Analysis of virulence and inflammatory potential of Shigella flexneri purine biosynthesis mutants. Infect Immun. 2003; 71(12):7002-13. PMC: 308888. DOI: 10.1128/IAI.71.12.7002-7013.2003. View

11.

Qadri F, Bhuiyan T, Dutta K, Raqib R, Alam M, Alam N . Acute dehydrating disease caused by Vibrio cholerae serogroups O1 and O139 induce increases in innate cells and inflammatory mediators at the mucosal surface of the gut. Gut. 2003; 53(1):62-9. PMC: 1773936. DOI: 10.1136/gut.53.1.62. View

12.

Branger J, Knapp S, Weijer S, Leemans J, Pater J, Speelman P . Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice. Infect Immun. 2004; 72(2):788-94. PMC: 321591. DOI: 10.1128/IAI.72.2.788-794.2004. View

13.

Knop J, Rowley D . Antibacterial mechanisms in the intestine. Elimination of V. cholerae from the gastrointestinal tract of adult mice. Aust J Exp Biol Med Sci. 1975; 53(2):137-46. View

14.

Mekalanos J, SWARTZ D, Pearson G, Harford N, Groyne F, de Wilde M . Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development. Nature. 1983; 306(5943):551-7. DOI: 10.1038/306551a0. View

15.

Goldberg I, Mekalanos J . Cloning of the Vibrio cholerae recA gene and construction of a Vibrio cholerae recA mutant. J Bacteriol. 1986; 165(3):715-22. PMC: 214488. DOI: 10.1128/jb.165.3.715-722.1986. View

16.

Levine M, Kaper J, Herrington D, Losonsky G, Morris J, Clements M . Volunteer studies of deletion mutants of Vibrio cholerae O1 prepared by recombinant techniques. Infect Immun. 1988; 56(1):161-7. PMC: 259251. DOI: 10.1128/iai.56.1.161-167.1988. View

17.

Tacket C, Losonsky G, Nataro J, Cryz S, Edelman R, Fasano A . Safety and immunogenicity of live oral cholera vaccine candidate CVD 110, a delta ctxA delta zot delta ace derivative of El Tor Ogawa Vibrio cholerae. J Infect Dis. 1993; 168(6):1536-40. DOI: 10.1093/infdis/168.6.1536. View

18.

Taylor D, Killeen K, Hack D, Kenner J, Coster T, Beattie D . Development of a live, oral, attenuated vaccine against El Tor cholera. J Infect Dis. 1994; 170(6):1518-23. DOI: 10.1093/infdis/170.6.1518. View

19.

Kaper J, Morris Jr J, Levine M . Cholera. Clin Microbiol Rev. 1995; 8(1):48-86. PMC: 172849. DOI: 10.1128/CMR.8.1.48. View

20.

Van De Verg L, Mallett C, Collins H, Larsen T, Hammack C, Hale T . Antibody and cytokine responses in a mouse pulmonary model of Shigella flexneri serotype 2a infection. Infect Immun. 1995; 63(5):1947-54. PMC: 173248. DOI: 10.1128/iai.63.5.1947-1954.1995. View