RNA Turnover: Unexpected Consequences of Being Tailed

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 2005 Aug 23

PMID 16111937

Citations 25

Authors

James T Anderson

Affiliations

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Abstract

In eukaryotic cells, the 3' poly(A) tails found on mRNA influence their stability and translation. The discovery of a second nuclear poly(A) polymerase complex has fueled a series of reports defining a new and unexpected role for 3' end poly(A) tails in the nuclear surveillance and turnover of noncoding RNAs and intergenic mRNAs of unknown function.

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