Adaptive Immune Responses in Acute and Chronic Hepatitis C Virus Infection

Overview

Journal Nature

Specialty Science

Date 2005 Aug 19

PMID 16107834

Citations 317

Authors

David G Bowen

Christopher M Walker

Affiliations

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Abstract

The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant cause of human illness and death globally. Recent studies have yielded important insights into immunity to HCV, in particular revealing the central role of T cells in viral control and clearance. Other key features of adaptive immune responses remain obscure, including mechanisms by which T cells control HCV replication, the role of antibodies in conferring protection and how cellular and humoral immunity are subverted in persistent infection.

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