» Articles » PMID: 16101535

Pathways of T Cell Activation and Terminal Differentiation in Chronic Inflammation

Overview
Date 2005 Aug 17
PMID 16101535
Citations 8
Authors
Affiliations
Soon will be listed here.
Abstract

Immune and inflammatory responses are governed by antigen-specific T cells, whose activation, differentiation and effector function are induced by signals delivered via the T cell antigen receptor (TCR) and by costimulatory and cytokine receptors. The molecular events leading to the activation of naïve T cells have been extensively studied and are well characterized. Much less is known about the molecular and biochemical events regulating the activation of T cells in chronic inflammatory diseases such as rheumatoid arthritis (RA). This review examines the current state of knowledge of T cell activation in chronic inflammation, focusing on RA, and summarizes experimental data which indicate that the chronic inflammatory process may profoundly affect TCR and cytokine signal transduction pathways. We present evidence suggesting that in chronic inflammation, the antigen-driven TCR-mediated processes are attenuated, while cytokine-driven effector responses are sustained or even enhanced. The possible implications of this inbalance are discussed.

Citing Articles

Using dendritic cells to evaluate how Burkholderia cenocepacia clonal isolates from a chronically infected cystic fibrosis patient subvert immune functions.

Cabral M, Pereira M, Silva Z, Iria I, Coutinho C, Lopes A Med Microbiol Immunol. 2016; 206(2):111-123.

PMID: 27987042 DOI: 10.1007/s00430-016-0488-4.


Imbalance of different types of CD4(+) forkhead box protein 3 (FoxP3)(+) T cells in patients with new-onset systemic lupus erythematosus.

Ma L, Zhao P, Jiang Z, Shan Y, Jiang Y Clin Exp Immunol. 2013; 174(3):345-55.

PMID: 23968502 PMC: 3826301. DOI: 10.1111/cei.12189.


Characterization of murine macrophages from bone marrow, spleen and peritoneum.

Wang C, Yu X, Cao Q, Wang Y, Zheng G, Tan T BMC Immunol. 2013; 14:6.

PMID: 23384230 PMC: 3574850. DOI: 10.1186/1471-2172-14-6.


Increased CD45RA+ FoxP3(low) regulatory T cells with impaired suppressive function in patients with systemic lupus erythematosus.

Pan X, Yuan X, Zheng Y, Wang W, Shan J, Lin F PLoS One. 2012; 7(4):e34662.

PMID: 22506043 PMC: 3323568. DOI: 10.1371/journal.pone.0034662.


Biocompatibility of implants: lymphocyte/macrophage interactions.

Anderson J, McNally A Semin Immunopathol. 2011; 33(3):221-33.

PMID: 21271251 DOI: 10.1007/s00281-011-0244-1.