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Physiological Functions of the Mitochondrial Uncoupling Proteins UCP2 and UCP3

Overview
Journal Cell Metab
Publisher Cell Press
Date 2005 Aug 16
PMID 16098826
Citations 338
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Abstract

Evidence for the physiological functions of UCP2 and UCP3 is critically reviewed. They do not mediate adaptive thermogenesis, but they may be significantly thermogenic under specific pharmacological conditions. There is strong evidence that the mild regulated uncoupling they cause attenuates mitochondrial ROS production, protects against cellular damage, and diminishes insulin secretion. Evidence that they export fatty acids physiologically is weak. UCP2 and UCP3 are important potential targets for treatment of aging, degenerative diseases, diabetes, and perhaps obesity.

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