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The Evolution of Noncoding DNA: How Much Junk, How Much Func?

Overview
Journal Trends Genet
Specialty Genetics
Date 2005 Aug 16
PMID 16098630
Citations 20
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Abstract

Comparative sequence analysis on a genomic scale has opened the door for the systematic analysis of cis-acting regulatory DNA. It is now possible to begin to answer basic questions such as, how much meaningful noncoding sequence is in the genome? How strong is natural selection on functional noncoding sequences in different species? Two recent articles have capitalized on the comparative genomic approach in an attempt to answer these questions with surprising results.

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