Ursodeoxycholic Acid and Superoxide Anion

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2005 Aug 13

PMID 16097062

Citations 6

Authors

Predrag Ljubuncic

Omar Abu-Salach

Arieh Bomzon

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the ability of ursodeoxycholic acid (UDCA) to scavenge superoxide anion (O(2)(-)).

Methods: We assessed the ability of UDCA to scavenge (O(2)(-)) generated by xanthine-xanthine oxidase (X-XO) in a cell-free system and its effect on the rate of O(2)(-)-induced ascorbic acid (AA) oxidation in hepatic post-mitochondrial supernatants.

Results: UDCA at a concentration as high as 1 mmol/L did not impair the ability of the X-XO system to generate O(2)(-), but could scavenge O(2)(-) at concentrations of 0.5 and 1 mmol/L, and decrease the rate of AA oxidation at a concentration of 100 micromol/L.

Conclusion: UDCA can scavenge O(2)(-), an action that may be beneficial to patients with primary biliary cirrhosis.

Citing Articles

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Restorative effects of hydroxysafflor yellow A on hepatic function in an experimental regression model of hepatic fibrosis induced by carbon tetrachloride.

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Primary biliary cirrhosis: From bench to bedside.

Kouroumalis E, Notas G World J Gastrointest Pharmacol Ther. 2015; 6(3):32-58.

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In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids.

Peng S, Huo X, Rezaei D, Zhang Q, Zhang X, Yu C Am J Physiol Gastrointest Liver Physiol. 2014; 307(2):G129-39.

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