Vitamin D Receptor Gene Tru9I Polymorphism and Risk for Incidental Sporadic Colorectal Adenomas

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2005 Aug 13

PMID 16097046

Citations 13

Authors

You-Ling Gong

Da-wen Xie

Zong-Lin Deng

Roberd M Bostick

Xi-Jiang Miao

Jin-Hui Zhang

Zhi-Hong Gong

Affiliations

Soon will be listed here.

Abstract

Aim: Recent laboratory and epidemiological studies suggest that vitamin D is a potential agent for colorectal cancer prevention. Its function is partially mediated by the vitamin D receptor (VDR). The aim of this study was to investigate whether a novel G (allele "U") >A (allele "u") polymorphism (Tru9I) in the VDR intron 8 region is associated with risk for colorectal adenoma in a colonoscopy-based case-control study.

Methods: Genotyping for a total of 391 subjects was carried out through PCR and restriction fragment length polymorphism.

Results: The frequencies of "U" and "u" alleles were 89.3% and 10.7%, respectively. The "Uu" and "uu" genotypes were associated with decreased risk for adenoma (OR, 0.71; 95%CI, 0.40-1.25). The inverse association was more pronounced for multiple adenomas and adenomas that were larger had moderate or greater dysplasia, or were sessile: the odds ratios (ORs) were, 0.51 (95%CI, 0.21-1.24), 0.37 (95%CI, 0.11-1.28), 0.68 (95%CI, 0.33-1.41), and 0.36 (95%CI, 0.13-0.97) respectively. In joint/combined analyses, inverse associations were more obvious among those who had at least one "u" allele and also were younger (OR, 0.60; 95%CI, 0.26-1.37), women (OR, 0.38; 95%CI, 0.17-0.88), did not smoke (OR, 0.39; 95%CI, 0.13-1.23), or took NSAID (OR, 0.38; 95%CI, 0.12-1.25), but no evidence existed for interactions with calcium or vitamin D intake.

Conclusion: Our findings suggest that the VDR Tru9I polymorphism may be associated with lower risk for colorectal adenoma, particularly in interaction with various risk factors, but not with calcium or vitamin D.

Citing Articles

Vitamin D Receptor Gene Single Nucleotide Polymorphisms and Association With Vitamin D Levels and Endoscopic Disease Activity in Inflammatory Bowel Disease Patients: A Pilot Study.

Thomas A, Criss Z, Shroyer N, Abraham B Inflamm Bowel Dis. 2020; 27(8):1263-1269.

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Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate Variant -rs2236225 on Homocysteine Levels.

Jones P, Lucock M, Martin C, Thota R, Garg M, Yates Z Nutrients. 2020; 12(5).

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Association of low penetrance vitamin D receptor Tru9I (rs757343) gene polymorphism with risk of premenopausal breast cancer.

Iqbal M, Maqbool S, Khan T J Int Med Res. 2018; 46(5):1801-1814.

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Paleolithic and Mediterranean Diet Pattern Scores Are Inversely Associated with Biomarkers of Inflammation and Oxidative Balance in Adults.

Whalen K, McCullough M, Flanders W, Hartman T, Judd S, Bostick R J Nutr. 2016; 146(6):1217-26.

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Association of Dietary Vitamin D and Calcium With Genetic Polymorphisms in Colorectal Neoplasia.

Park Y, Kim J J Cancer Prev. 2015; 20(2):97-105.

PMID: 26151042 PMC: 4492365. DOI: 10.15430/JCP.2015.20.2.97.

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