Boolean Control of Aptamer Binding States

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2005 Aug 11

PMID 16089464

Citations 17

Authors

Dmitry M Kolpashchikov

Milan N Stojanovic

Affiliations

Soon will be listed here.

Abstract

Molecules that perform Boolean calculations can analyze a series of inputs and make a decision to produce or not to produce an output, based on the presence or absence of inputs and a particular formula they encode. We now report that molecular computation performed by deoxyribozyme-based logic gates can be used to control the functional state of aptamers, switching them on or off based on the outcome of such computation.

Citing Articles

A signal-enhanced and sensitive lateral flow aptasensor for the rapid detection of PDGF-BB.

Cheng N, Liu Y, Mukama O, Han X, Huang H, Li S RSC Adv. 2022; 10(32):18601-18607.

PMID: 35518307 PMC: 9053969. DOI: 10.1039/d0ra02662j.

Logic Gates Based on DNA Aptamers.

Andrianova M, Kuznetsov A Pharmaceuticals (Basel). 2020; 13(11).

PMID: 33238657 PMC: 7700249. DOI: 10.3390/ph13110417.

DNA-Based Dynamic Reaction Networks.

Fu T, Lyu Y, Liu H, Peng R, Zhang X, Ye M Trends Biochem Sci. 2018; 43(7):547-560.

PMID: 29793809 PMC: 6522144. DOI: 10.1016/j.tibs.2018.04.010.

Nucleic acid aptamer-based methods for diagnosis of infections.

Park K Biosens Bioelectron. 2017; 102:179-188.

PMID: 29136589 PMC: 7125563. DOI: 10.1016/j.bios.2017.11.028.

Bridging the Two Worlds: A Universal Interface between Enzymatic and DNA Computing Systems.

Mailloux S, Gerasimova Y, Guz N, Kolpashchikov D, Katz E Angew Chem Int Ed Engl. 2015; 54(22):6562-6.

PMID: 25864379 PMC: 4495919. DOI: 10.1002/anie.201411148.