KIR Matching in Hematopoietic Stem Cell Transplantation

Overview

Journal Curr Opin Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2005 Aug 9

PMID 16085405

Citations 9

Authors

Jean-Denis Bignon

Katia Gagne

Affiliations

Soon will be listed here.

Abstract

Although the key role of MHC-restricted T lymphocytes in hematopoietic stem cell transplantation (HSCT) has been known for a long time, recent data have focused on complementary or alternative effector cell populations, and in particular on NK cells. Spontaneously generated NK cell alloreactivity from stem cell grafts involves specific interactions between NK receptors, including killer immunoglobulin-like receptors (KIRs) and their MHC class I ligands. The combined effects of HLA and KIR polymorphic genes might explain discrepancies in the impact of donor-recipient matching observed in HSCT.

Citing Articles

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Sucheston-Campbell L, Clay A, McCarthy P, Zhu Q, Preus L, Pasquini M Curr Hematol Malig Rep. 2015; 10(1):45-58.

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Current status of haploidentical stem cell transplantation for leukemia.

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