Immunogenetics of Viral Infections

Overview

Journal Curr Opin Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2005 Aug 9

PMID 16084708

Citations 40

Authors

Maureen P Martin

Mary Carrington

Affiliations

Soon will be listed here.

Abstract

The HLA class I and II genes encode molecules that lie at the heart of the acquired immune response against infectious diseases. Associations between these polymorphic loci and genetically complex infectious diseases have been historically elusive, in contrast to the more obvious HLA associations with autoimmune diseases. High resolution molecular typing of large, clinically well-defined cohorts has begun to uncover evidence for the influence of HLA diversity on diseases of viral etiology, such as those caused by HIV-1, hepatitis B virus, hepatitis C virus and human papilloma virus. Combinations of HLA and KIR also appear to affect outcome to viral infection, supporting a role for HLA class I diversity in the innate immune response in addition to the acquired immune response.

Citing Articles

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Association between Human Leukocyte Antigen (HLA) DQB1*06 and HLA DQB1*03 and adverse outcomes in a group of critically ill patients with COVID-19 in Tunisia: a cross-sectional study.

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The New Kid on the Block: HLA-C, a Key Regulator of Natural Killer Cells in Viral Immunity.

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The Role of Immunogenetics in COVID-19.

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Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19.

Ramos-Lopez O, Daimiel L, Ramirez de Molina A, Martinez-Urbistondo D, Vargas J, Martinez J Int J Genomics. 2020; 2020:6901217.

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