Serum Cortisol and Cortisone Levels in Newborns with Congenital Adrenal Hyperplasia Before the Start of Therapy

Overview

Journal J Endocrinol Invest

Publisher Springer

Specialty Endocrinology

Date 2005 Aug 4

PMID 16075923

Citations 1

Authors

J Dotsch

I Hohenberger

F G Riepe

W G Sippell

H G Dorr

Affiliations

Soon will be listed here.

Abstract

Sodium loss in infants with salt wasting (SW) congenital adrenal hyperplasia (CAH) does usually not occur within the first week of life. We hypothesized that sufficient mineralocorticoid activity might by temporarily maintained by still appropriate concentrations of cortisol. Plasma samples were obtained from 15 infants with SW-CAH before the onset of sodium loss, 17 patients with simple virilizing (SV)-CAH and 28 healthy infants under 14 days of age. Plasma aldosterone concentrations were significantly lower in SW-CAH infants than in SV-CAH patients and in healthy neonates. Plasma cortisol levels and cortisol/cortisone (F/E) ratios in SW-CAH patients were almost the same as in the SV-CAH and control group. While declining plasma aldosterone levels precede the onset of SW in CAH patients, plasma cortisol concentrations are kept normal in SW-CAH infants, temporarily maintaining sufficient mineralocorticoid activity.

Citing Articles

Birth length and weight in congenital adrenal hyperplasia according to the different phenotypes.

Balsamo A, Wasniewska M, Di Pasquale G, Salzano G, Baronio F, Bombaci S Eur J Pediatr. 2006; 165(6):380-3.

PMID: 16520942 DOI: 10.1007/s00431-005-0075-y.

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