[Effect of Geniposide on Serum IL-1beta and TNF-alpha of Rheumatoid Arthritis Rats]

Overview

Journal Zhongguo Zhong Yao Za Zhi

Date 2005 Aug 4

PMID 16075741

Citations 6

Authors

Jiang Zhu

Xin Gao

Wen-Li Xie

Yu-zhang Jin

Wen-Jun Sun

Affiliations

Soon will be listed here.

Abstract

Objective: To study the effect of geniposide on serum IL-1beta and TNF-alpha levels of rheumatoid arthritis rats, as well as the mechanism of this drug.

Method: To establish an experimental rat model of type II collagen-induced arthritic (CIA). The inhibitory effects on paw edema were observed, and serum IL-1beta and TNF-alpha levels were determined in experimental rats.

Result: Compared with the model, geniposide delayed the starting time of right paw edema significantly, and the levels of serum IL-1beta and TNF-alpha were significantly decreased by geniposide at high dose or medium dose (P < 0.01).

Conclusion: Geniposide can lower serum IL-1beta and TNF-alpha levels in rheumatoid arthritis rats. The effect may be close related to inhibitory development of rheumatoid arthritis by the agent.

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