Self Injurious Behavior in Autism: Clinical Aspects and Treatment with Risperidone

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2005 Aug 3

PMID 16075185

Citations 18

Authors

R Canitano

Affiliations

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Abstract

Self injurious behavior (SIB) is frequent in autistic spectrum disorders. The aim of this study was to investigate the phenomenology of SIB in a group of children with autistic disorder, and to test whether treatment with risperidone might reduce it. A group of eleven children diagnosed with autistic disorder according to the DSM-IV criteria (mean age 8.7+/-2.2 ys) and with severe SIB were recruited for an open study of six months of treatment with risperidone. The Yale-Paris Self-Injurious Behavior Scale was used to delineate the clinical characteristics and as an outcome measure. Head-hitting and hand biting were the most frequent forms of self aggression observed. Nine children presented a mild improvement in SIB and 2 did not show any variation. A decrease in Yale-Paris Self Injurious Behavior Scale score (from M 15.1+/-1.4 to 13.3+/-1.4) was noted mainly due to the reduction of frequency. Side effects of risperidone were not severe.

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References

Murphy G, Hall S, Oliver C . Identification of early self-injurious behaviour in young children with intellectual disability. J Intellect Disabil Res. 1999; 43 ( Pt 3):149-63. DOI: 10.1046/j.1365-2788.1999.00183.x. View

Masi G, Cosenza A, Mucci M, Brovedani P . Open trial of risperidone in 24 young children with pervasive developmental disorders. J Am Acad Child Adolesc Psychiatry. 2001; 40(10):1206-14. DOI: 10.1097/00004583-200110000-00015. View

Schopler E, Reichler R, DeVellis R, Daly K . Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). J Autism Dev Disord. 1980; 10(1):91-103. DOI: 10.1007/BF02408436. View

King B . Pharmacological treatment of mood disturbances, aggression, and self-injury in persons with pervasive developmental disorders. J Autism Dev Disord. 2000; 30(5):439-45. DOI: 10.1023/a:1005555624566. View

Gillberg C . Endogenous opioids and opiate antagonists in autism: brief review of empirical findings and implications for clinicians. Dev Med Child Neurol. 1995; 37(3):239-45. DOI: 10.1111/j.1469-8749.1995.tb11998.x. View

McDougle C, Holmes J, Bronson M, Anderson G, Volkmar F, Price L . Risperidone treatment of children and adolescents with pervasive developmental disorders: a prospective open-label study. J Am Acad Child Adolesc Psychiatry. 1997; 36(5):685-93. DOI: 10.1097/00004583-199705000-00020. View

Malone R, Maislin G, Choudhury M, Gifford C, Delaney M . Risperidone treatment in children and adolescents with autism: short- and long-term safety and effectiveness. J Am Acad Child Adolesc Psychiatry. 2002; 41(2):140-7. DOI: 10.1097/00004583-200202000-00007. View

Buitelaar J, van Engeland H . The effects of chronic naltrexone treatment in young autistic children: a double-blind placebo-controlled crossover study. Biol Psychiatry. 1996; 39(12):1023-31. DOI: 10.1016/0006-3223(95)00297-9. View

Buitelaar J . Medication treatment in subjects with autistic spectrum disorders. Eur Child Adolesc Psychiatry. 2001; 9 Suppl 1:I85-97. DOI: 10.1007/s007870070022. View

10.

Pies R, Popli A . Self-injurious behavior: pathophysiology and implications for treatment. J Clin Psychiatry. 1995; 56(12):580-8. View

11.

Tordjman S, Antoine C, Cohen D, Gauvain-Piquard A, Carlier M, Roubertoux P . [Study of the relationships between self-injurious behavior and pain reactivity in infantile autism]. Encephale. 1999; 25(2):122-34. View

12.

Campbell M, Rapoport J, Simpson G . Antipsychotics in children and adolescents. J Am Acad Child Adolesc Psychiatry. 1999; 38(5):537-45. DOI: 10.1097/00004583-199905000-00015. View

13.

Buitelaar J . Self-injurious behaviour in retarded children: clinical phenomena and biological mechanisms. Acta Paedopsychiatr. 1993; 56(2):105-11. View

14.

Gillberg C . Typical neuroleptics in child and adolescent psychiatry. Eur Child Adolesc Psychiatry. 2001; 9 Suppl 1:I2-8. DOI: 10.1007/s007870070014. View

15.

Cook E, Leventhal B . The serotonin system in autism. Curr Opin Pediatr. 1996; 8(4):348-54. DOI: 10.1097/00008480-199608000-00008. View

16.

Bodfish J, Symons F, Parker D, Lewis M . Varieties of repetitive behavior in autism: comparisons to mental retardation. J Autism Dev Disord. 2000; 30(3):237-43. DOI: 10.1023/a:1005596502855. View

17.

Sivam S . Dopamine, serotonin and tachykinin in self-injurious behavior. Life Sci. 1996; 58(26):2367-75. DOI: 10.1016/0024-3205(96)00121-x. View

18.

. [Therapeutic intervention in infantile autism and generalized developmental disorders: self-injury and self-stimulation]. Rev Neurol. 2000; 28 Suppl 2:S130-4. View

19.

Ernst M . Commentary: considerations on the characterization and treatment of self-injurious behavior. J Autism Dev Disord. 2000; 30(5):447-50. DOI: 10.1023/a:1005507708636. View

20.

Masi G, Cosenza A, Mucci M, Brovedani P . A 3-year naturalistic study of 53 preschool children with pervasive developmental disorders treated with risperidone. J Clin Psychiatry. 2003; 64(9):1039-47. DOI: 10.4088/jcp.v64n0909. View