Transcriptional Regulation and Transformation by Myc Proteins

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2005 Aug 3

PMID 16064138

Citations 515

Authors

Sovana Adhikary

Martin Eilers

Affiliations

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Abstract

Myc genes are key regulators of cell proliferation, and their deregulation contributes to the genesis of most human tumours. Recently, a wealth of data has shed new light on the biochemical functions of Myc proteins and on the mechanisms through which they function in cellular transformation.

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