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Dietary Approaches to Epilepsy Treatment: Old and New Options on the Menu

Overview
Journal Epilepsy Curr
Publisher Sage Publications
Date 2005 Aug 2
PMID 16059506
Citations 22
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Abstract

Dietary therapies represent a potentially valuable adjunct to other epilepsy treatments, such as anticonvulsant medications, epilepsy surgery, and vagus nerve stimulation. Although the ketogenic diet (high fat, adequate protein, low carbohydrate) is the most well-established dietary therapy for epilepsy, other possible approaches include the Atkins diet (high fat, high protein, low carbohydrate), a diet enriched in polyunsaturated fatty acids, or overall restriction of calorie intake. This review discusses the current clinical status of each of these dietary approaches and suggests possible mechanisms by which they might suppress neuronal hyperexcitability and seizures.

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References
1.
Sirven J, Whedon B, Caplan D, Liporace J, Glosser D, ODwyer J . The ketogenic diet for intractable epilepsy in adults: preliminary results. Epilepsia. 1999; 40(12):1721-6. DOI: 10.1111/j.1528-1157.1999.tb01589.x. View

2.
Uauy R, Mena P . Lipids and neurodevelopement. Nutr Rev. 2001; 59(8 Pt 2):S34-46; discussion S46-8. DOI: 10.1111/j.1753-4887.2001.tb05500.x. View

3.
Bough K, Gudi K, Han F, Rathod A, Eagles D . An anticonvulsant profile of the ketogenic diet in the rat. Epilepsy Res. 2002; 50(3):313-25. DOI: 10.1016/s0920-1211(02)00086-4. View

4.
Bruce-Keller A, Umberger G, McFall R, Mattson M . Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann Neurol. 1999; 45(1):8-15. View

5.
Schwartzkroin P . Mechanisms underlying the anti-epileptic efficacy of the ketogenic diet. Epilepsy Res. 1999; 37(3):171-80. DOI: 10.1016/s0920-1211(99)00069-8. View