Pleiotropic Mechanisms of Virus Survival and Persistence

Overview

Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod

Publisher Elsevier

Specialties Dentistry
General Surgery

Date 2005 Jul 23

PMID 16037790

Citations 5

Authors

Craig S Miller

Affiliations

Soon will be listed here.

Abstract

Viruses are enormously efficient infectious agents that have been implicated in causing human disease for centuries. Transmission of these pathogens continues to be from one life form to another in the form of isolated cases, epidemics, and pandemics. Each infection requires entry into a susceptible host, replication, and evasion of the immune system. Viruses are successful pathogens because they target specific cells for their attack, exploit the cellular machinery, and are efficient in circumventing and/or inhibiting key cellular events required of survival. This article reviews some of the advances that have taken place in human virology in the past 50 years, emphasizing mechanisms that contribute to, and are involved with, virus survival and persistence.

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